Mykhailiuk made 9 of 14 shots and had a career-high nine rebounds.
Moses Brown had 20 points and 11 rebounds, and Isaiah Roby added 17 points and 10 rebounds for Oklahoma City, which snapped a three-game losing streak. The Thunder outrebounded the Raptors 64-35.
Oklahoma City was missing three regular starters. Shai Gilgeous-Alexander remained out with right foot plantar fasciitis, Lu Dort was out due to concussion protocols and Darius Bazley was out with a left shoulder contusion. Rookie Aleksej Pokusevski, a recent addition to the starting lineup, was out because of health and safety protocols.
Gary Trent Jr. scored a career-high 31 points, and OG Anunoby added 20 points and 11 rebounds for the Raptors, who have dropped 13 of their last 14 games.
Raptors guard Kyle Lowry sat out with a right foot infection. He played 24 minutes against Portland on Monday, but had missed the game before that against Portland on Sunday with right foot soreness.
Trent scored 20 points in the first half to help the Raptors take a 67-59 lead. Toronto shot 52% from the field in the first half. Brown led the Thunder with 12 points and eight rebounds.
Toronto led 89-87 heading into the fourth. The Thunder held the Raptors to 30% shooting in the third quarter to close the gap.
Oklahoma City took the lead early in the fourth. Mykhailiuk went up high to throw down a two-handed dunk on a lob from Justin Jackson that put the Thunder ahead 98-93. Mykhailiuk followed with a 3-pointer to push Oklahoma City’s lead to eight. Toronto got no closer than four points the rest of the way.
Raptors: Trent scored 10 points in the first quarter as Toronto shot 50%. … Center Aron Baynes was issued a technical foul in the third quarter. … Anunoby extended his streak of games with at least 10 points to 22 games.
Thunder: It was the first Oklahoma City game since Fox Sports Oklahoma rebranded as Bally Sports Oklahoma. Only the name changed. … Guard/forward Kenrich Williams had 10 points and nine rebounds. … Guard Theo Maledon had 11 points, seven rebounds and six assists.
Raptors: Host the Golden State Warriors on Friday.
Thunder: Visit the Phoenix Suns on Friday.