In addition to Siakam, Fred VanVleet (hip), Jalen Harris (hip) and Paul Watson (health and safety protocols) are all out as well.
Siakam is averaging 20.7 points, 7.3 rebounds and 4.5 assists in 43 games, all starts, for the Raptors this season.
Hood has been out for Toronto’s previous four games due to a right hip ailment. He has appeared in four games off the bench since being acquired from the Portland Trail Blazers in the Norman Powell trade on March 25.
The Raptors (20-32) sit 11th in the Eastern Conference heading into Saturday night’s game against the Cavaliers (19-32), 2.5 games behind 10th-place Chicago. Tip-off is scheduled for 7:30 p.m. ET/4:30 p.m. PT on Sportsnet 360.